News
07.03.2026 - Publication of nested results on resistance in the Journal of Antimicrobial Chemotherapy
We report resistance-associated mutations and resistance levels from both study arms (post-hoc for the usual care arm), including longitudinal data where available. While substantial resistance was observed, including one case of dolutegravir resistance, most participants had three fully active drugs in their regimen. These findings further highlight the need for both better adherence interventions and more targeted approaches to resistance testing. doi: 10.1093/jac/dkag070.
10-13.11.2024 - Secondary resistance findings presented at HIV Glasgow
Christof Schönenberger represented the GIVE MOVE team presenting in-depth resistance findings, including post-hoc resistance testing for the control arm, at HIV Glasgow.
17.07.2024 - Publication of main findings in The Lancet Global Health
The main trial results are out!
Genotypic resistance testing-informed clinical management did not significantly improve treatment outcomes over standard care for children and adolescents with viraemia while taking antiretroviral therapy.
08.07.2023 - Last follow-up visit
Trial follow-up is completed. Results will be available soon.
05.07.2022 - Last enrolment
Enrolment to the trial is completed.
12.04.2022 - Activation of three new sites in Tanzania
Three MDH-supported sites in Dar es Salaam - Temeke Regional Referral Hospital, Mbagala Rangi Tatu Hospital, and Upendano Dispensary - are activated.
Image: Training of Dar es Salaam site teams.
23.03.2021 - Activation of Mohale’s Hoek site in Lesotho
The Baylor clinic in Mohale’s Hoek is activated.
30.11.-03.12.2020 - Activation of two new sites in Lesotho
The Seboche Mission Hospital (30.11.2020) and Baylor Maseru (03.12.2020) sites are formally activated.
19.10.2020 - Publication of the GIVE MOVE study protocol
The study protocol manuscript is published with BMC Infectious Diseases.
29.07.2020 - Site activation in Ifakara, Tanzania
Recruitment begins in Ifakara, Tanzania.
Image: Data collection during an enrolment visit in Ifakara.
17.03.2020 - Delay of site activation in Ifakara, Tanzania
The site activation of the One-Stop Clinic and Chronic Diseases Clinic (CDCI) at St Francis Referral Hospital, Ifakara, Tanzania is delayed due to COVID-19.
03.03.2020 - First participant first visit
The first participant is enrolled to the study.
20.02.-09.03.2020 - Site activations in Lesotho
The sites in Lesotho, the Baylor clinics in Leribe (20.02.2020), Butha-Buthe (27.02.2020) and Mokhotlong (09.03.2020), are formally activated.
Image: Site Initiation Visit in Butha-Buthe.
18.01.2020 - Trial registration is completed
GIVE MOVE is registered at ClinicalTrials.gov: NCT04233242.
17.-18.01.2020 - GIVE MOVE training
The Local Principal Investigators and Deputy Local Principal Investigators of the first three sites in Lesotho (Leribe, Butha-Buthe, Mokhotlong) get together for a two-day training on study procedures, using the study database (MACRO by Elsevier), correct study documentation, refresher of Good Clinical Practice principles, study documentation, quality assurance and monitoring, consenting procedures.